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Anal pain
Rectal or anal pain can also occur with inflammatory diseases of the bowel, localized infections, or minor injuries to the area. Some causes of rectal pain, such as hemorrhoids or anal fissures, can be accompanied by other symptoms like blood in the stool or bleeding. Diarrhea or constipation may also be present.
Anal fistula

An anal fistula is a small tunnel that develops between the end of the bowel and the skin near the anus (where poo leaves the body). They're usually the result of an infection near the anus causing a collection of pus (abscess) in the nearby tissue. When the pus drains away, it can leave a small channel behind.

Anal fissure
A small tear in the lining of the anus.
Anal fissure may occur when passing hard or large stools.
An anal fissure can cause pain and bleeding during bowel movements.
This condition usually heals on its own in four to six weeks. Common treatments include dietary fibre and stool softeners, as well as creams to the affected area.
Anal cancer
Anal cancer is a disease in which malignant (cancer) cells form in the tissues of the anus. Most anal cancers are related to human papillomavirus (HPV) infection. Signs of anal cancer include bleeding from the anus or rectum or a lump near the anus.
Anaesthesia
Anaesthesia
Anesthesia or anaesthesia (from Greek "without sensation") is a state of controlled, temporary loss of sensation or awareness that is induced for medical purposes. It may include some or all of analgesia (relief from or prevention of pain), paralysis (muscle relaxation), amnesia (loss of memory), and unconsciousness.
Anabolic steroid misuse

Anabolic steroids are either prescribed or illegally obtained by individuals who want to appear stronger and develop muscle mass in a short period of time, often resulting in increased confidence and self-esteem. There are over 100 types of anabolic steroids, only a fraction of which have been approved for medical use.

Anabolic steroids are addictive due two primary factors. The first is a behavior of many individuals with substance use disorders, the compulsive need to seek out and use anabolic steroids. The second is the appearance of withdrawal symptoms due to when the user cuts back or stops using steroids completely. The obsessive-compulsive behavior to keep using anabolic steroids often begins when the steroids improve physical appearance and strength in a short amount of time, which may eventually result in an addiction developing.

Amyloidosis

Amyloidosis is when an abnormal protein called amyloid builds up in your tissues and organs. When it does, it affects their shape and how they work. Amyloidosis is a serious health problem that can lead to life-threatening organ failure. 

Symptoms depend on which organs are affected. They may include swelling, fatigue and weakness, shortness of breath, and numbness, tingling or pain in the hands or feet. Depending on the type of amyloidosis, medication, chemotherapy or a stem-cell transplant may be options.