Aciclovir has antiviral activity that is essentially confined to the herpes viruses. It is particularly active in vitro against herpes simplex type 1 and herpes simplex type 2. Aciclovir inhibits viral replication by inhibiting DNA synthesis. This inhibition is due to intracellular conversion of aciclovir by viral thymidine kinase to the monophosphate with subsequent conversion to the diphosphate and the active triphosphate. This active form inhibits the herpes virus DNA polymerase enzyme as well as being incorporated into viral DNA .
S4 Aciclovir is effective in the treatment of viral infections due to herpes simplex type 1 and type 2 of the skin and genitalia in the initial and recurrent situation.
S2 Application to the lips in the early treatment of recurrent Herpes simplex virus infections.
Aciclovir is contra-indicated in patients known to be allergic to aciclovir and propylene glycol.
Safety of ADCO-ACYCLOVIR TOPICAL CREAM in pregnancy and lactation has not been established.
Topical applications of aciclovir may sometimes produce burning or erythema.
DOSAGE AND DIRECTIONS FOR USE
Adults and Children:
The topical cream may be applied five or six times daily every three or four hours for periods of five to ten days. Topical treatment of lesions caused by herpes simplex should be initiated as early as possible. It is particularly important to start treatment of recurrent episodes during the prodromal period or when the lesions first appear.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Aciclovir may sometimes cause transient burning or stinging. Erythema or mild drying and flaking of the skin have been reported.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
See side-effects and special precautions. Should aciclovir need to be removed, then haemodialysis would be effective. Further treatment is symptomatic and supportive.
Smooth, white soft cream.
Collapsible tubes of 2 g and 10 g.
Store below 25°C. Protect from light. Keep out of reach of children.
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